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Corn Oil and Cancer: Reality Strikes Again

The benefits of corn oil keep rolling in. In a new study by Stephen Freedland's group at Duke, feeding mice a diet rich in butter and lard didn't promote the growth of transplanted human prostate cancer cells any more than a low-fat diet (1).

Why do we care? Because other studies, including one from the same investigators, show that corn oil and other industrial seed oils strongly promote prostate cancer cell growth and increase mortality in similar models (2, 3).

From the discussion section:
Current results combined with our prior results suggest that lowering the fat content of a primarily saturated fat diet offers little survival benefit in an intact or castrated LAPC-4 xenograft model. In contrast to the findings when omega-6 fats are used, these results raise the possibility that fat type may be as important as fat amount or perhaps even more important.
The authors seem somewhat surprised and pained by the result. Kudos for publishing it. However, there's nothing to be surprised about. There's a large body of evidence implicating excess omega-6 fat in a number of cancer models. Reducing omega-6 to below 4% of calories has a dramatic effect on cancer incidence and progression*. In fact, there have even been several experiments showing that butter and other animal fats promote cancer growth to a lesser degree than margarine and omega-6-rich seed oils. I discussed that here.

I do have one gripe with the study. They refer to the diet as "saturated fat based". That's inaccurate terminology. I see it constantly in the diet-health literature. If it were coconut oil, then maybe I could excuse it, because coconut fat is 93% saturated. But this diet was made of lard and butter, the combination of which is probably about half saturated. The term "animal fat" or "low-omega-6 fat" would have been more accurate. At least they listed the diet composition. Many studies don't even bother, leaving it to the reader to decide what they mean by "saturated fat".

* The average American eats 7-8% omega-6 by calories. This means it will be difficult to see a relationship between omega-6 intake and cancer (or heart disease, or most things) in observational studies in the US or other industrial nations, because we virtually all eat more than 4% of calories as omega-6. Until the 20th century, omega-6 intake was below 4%, and usually closer to 2%, in most traditional societies. That's where it remains in contemporary traditional societies unaffected by industrial food habits, such as Kitava. Our current omega-6 intake is outside the evolutionary norm.

Cold Calling Strategies For Beginners

"Cold calling" is not a pleasant task. Most people like to call on new prospects, because you never know how the person will respond to the other end. Denial is one thing to take. There are ways to make your cold calling easier "tasks and to do a little 'more efficient.

Research and target your prospects

You may want to know which companies are using their product or service. Once you have a list of target prospects, you do your homework and research each company.You do not want to go in your call, without knowing anything about the company. The more you know, the easier it is to ask questions and make conversation. Want from telemarketing usual, getting bombed every day to disagree.

Choose a good time to Call

Not only that you are in a good mood before making calls, but you want at a time during the call date on which potential customers are available. When they start, not theirEnterprise clock until after 10, there is no point to call first. Do not call too late at night or, as most people are willing to work and enjoy their family or leisure. I also believe that bad calls are Monday to say a phone call Friday. Friday: The weekend is near and people tend to be in a better mood.

Do you have a phone script

After what you say down on paper as a guide helps. You do not want to read the full script, butavailable for the flow of conversation going in the right direction to maintain. The practice and how to make your height and practice on a friend so that you pass to rebuttals. Better in dealing with complaints, the better prepared you are for each question, a prospect raises path.

Be nice to the receptionist

They are the guardians and rude, they are not quickly where. It 'a good idea to learn their names andwarmly. The most beautiful you are, the better the chance to meet people who think decisions.

"Cold calling" is never easy, that if you have the language and feel that is for everyone. Please note, believe in your product or service, and that you are offering something that can help. The more you practice the better you get!

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Magnesium and Insulin Sensitivity

From a paper based on US NHANES nutrition and health survey data (1):
During 1999–2000, the diet of a large proportion of the U.S. population did not contain adequate magnesium... Furthermore, racial or ethnic differences in magnesium persist and may contribute to some health disparities.... Because magnesium intake is low among many people in the United States and inadequate magnesium status is associated with increased risk of acute and chronic conditions, an urgent need exists to perform a current survey to assess the physiologic status of magnesium in the U.S. population.
Magnesium is an essential mineral that's slowly disappearing from the modern diet, as industrial agriculture and industrial food processing increasingly dominate our food choices. One of the many things it's necessary for in mammals is proper insulin sensitivity and glucose control. A loss of glucose control due to insulin resistance can eventually lead to diabetes and all its complications.

Magnesium status is associated with insulin sensitivity (2, 3), and a low magnesium intake predicts the development of type II diabetes in most studies (4, 5) but not all (6). Magnesium supplements largely prevent diabetes in a rat model* (7). Interestingly, excess blood glucose and insulin themselves seem to reduce magnesium status, possibly creating a vicious cycle.

In a 1993 trial, a low-magnesium diet reduced insulin sensitivity in healthy volunteers by 25% in just four weeks (8). It also increased urinary thromboxane concentration, a potential concern for cardiovascular health**.

At least three trials have shown that magnesium supplementation increases insulin sensitivity in insulin-resistant diabetics and non-diabetics (9, 10, 11). In some cases, the results were remarkable. In type II diabetics, 16 weeks of magnesium supplementation improved fasting glucose, calculated insulin sensitivity and HbA1c*** (12). HbA1c dropped by 22 percent.

In insulin resistant volunteers with low blood magnesium, magnesium supplementation for four months reduced estimated insulin resistance by 43 percent and decreased fasting insulin by 32 percent (13). This suggests to me that magnesium deficiency was probably one of the main reasons they were insulin resistant in the first place. But the study had another very interesting finding: magnesium improved the subjects' blood lipid profile remarkably. Total cholesterol decreased, LDL decreased, HDL increased and triglycerides decreased by a whopping 39 percent. The same thing had been reported in the medical literature decades earlier when doctors used magnesium injections to treat heart disease, and also in animals treated with magnesium. Magnesium supplementation also suppresses atherosclerosis (thickening and hardening of the arteries) in animal models, a fact that I may discuss in more detail at some point (14, 15).

In the previous study, participants were given 2.5 g magnesium chloride (MgCl2) per day. That's a bit more than the USDA recommended daily allowance (MgCl2 is mostly chloride by weight), in addition to what they were already getting from their diet. Most of a person's magnesium is in their bones, so correcting a deficiency by eating a nutritious diet may take a while.

Speaking of nutritious diets, how does one get magnesium? Good sources include halibut, leafy greens, chocolate and nuts. Bone broths are also an excellent source of highly absorbable magnesium. Whole grains and beans are also fairly good sources, while refined grains lack most of the magnesium in the whole grain. Organic foods, particularly artisanally produced foods from a farmer's market, are richer in magnesium because they grow on better soil and often use older varieties that are more nutritious.

The problem with seeds such as grains, beans and nuts is that they also contain phytic acid which prevents the absorption of magnesium and other minerals (16). Healthy non-industrial societies that relied on grains took great care in their preparation: they soaked them, often fermented them, and also frequently removed a portion of the bran before cooking (17). These steps all served to reduce the level of phytic acid and other anti-nutrients. I've posted a method for effectively reducing the amount of phytic acid in brown rice (18). Beans should ideally be soaked for 24 hours before cooking, preferably in warm water.

Industrial agriculture has systematically depleted our soil of many minerals, due to high-yield crop varieties and the fact that synthetic fertilizers only replace a few minerals. The mineral content of foods in the US, including magnesium, has dropped sharply in the last 50 years. The reason we need to use fertilizers in the first place is that we've broken the natural nutrient cycle in which minerals always return to the soil in the same place they were removed. In 21st century America, minerals are removed from the soil, pass through our toilets, and end up in the landfill or in waste water. This will continue until we find an acceptable way to return human feces and urine to agricultural soil, as many cultures do to this day****.

I believe that an adequate magnesium intake is critical for proper insulin sensitivity and overall health.

* Zucker rats that lack leptin signaling

** Thromboxane A2 is an omega-6 derived eicosanoid that potently constricts blood vessels and promotes blood clotting. It's interesting that magnesium has such a strong effect on it. It indicates that fatty acid balance is not the only major influence on eicosanoid production.

*** Glycated hemoglobin. A measure of the average blood glucose level over the past few weeks.

**** Anyone interested in further reading on this should look up The Humanure Handbook

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Lindeberg on Obesity

I'm currently reading Dr. Staffan Lindeberg's magnum opus Food and Western Disease, recently published in English for the first time. Dr. Lindeberg is one of the world's leading experts on the health and diet of non-industrial cultures, particularly in Papua New Guinea. The book contains 2,034 references. It's also full of quotable statements. Here's what he has to say about obesity:
Middle-age spread is a normal phenomenon - assuming you live in the West. Few people are able to maintain their [youthful] waistline after age 50. The usual explanation - too little exercise and too much food - does not fully take into account the situation among traditional populations. Such people are usually not as physically active as you may think, and they usually eat large quantities of food.

Overweight has been extremely rare among hunter-gatherers and other traditional cultures [18 references]. This simple fact has been quickly apparent to all foreign visitors...

The Kitava study measured height, weight, waist circumference, subcutaneous fat thickness at the back of the upper arm (triceps skinfold) and upper arm circumference on 272 persons ages 4-86 years. Overweight and obesity were absent and average [body mass index] was low across all age groups. ...no one was larger around their waist than around their hips.

...The circumference of the upper arm [mostly indicating muscle mass] was only negligibly smaller on Kitava [compared with Sweden], which indicates that there was no malnutrition. It is obvious from our investigations that lack of food is an unknown concept, and that the surplus of fruits and vegetables regularly rots or is eaten by dogs.

The Population of Kitava occupies a unique position in the world in terms of the negligible effect that the Western lifestyle has had on the island.
The only obese Kitavans Dr. Lindeberg observed were two people who had spent several years off the island living a modern, urban lifestyle, and were back on Kitava for a visit.

I'd recommend this book to anyone who has a scholarly interest in health and nutrition, and somewhat of a background in science and medicine. It's extremely well referenced, which makes it much more valuable.


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Home Business Leads, how to ensure You Get Them For Free!

Is now easier than ever to start generating business leads free home for your MLM business, thanks to the power of the Internet. However, there are still many people are struggling every day and many of them lose money in the process because they spend a lot of money trying to create them.

The most old school of marketing your MLM business consisted of my home business leads, cold calling, chasing friends and family, the rule of 3 feet, and so forth. AndAlthough these methods work for some people and not for everyone. Not everyone has the language or the attractiveness "that makes people want to pigeonhole you, and connect the economy. This really is a skill that develops over time.

So the question remains: "How do I generate business leads at home for free?". Well, the answer is quite simple ...

You run with a funnel or a proposal instead of a Financed marketing business opportunities. Andeducation through the funnel, your potential customers and show them that we can help. This not only allows you to position itself as the expert, but will also allow you to easily become a cost effective product upsell cash flow, so that you generate for your business. This is a crucial part of the production goals of quality home business leads.

It 'a wonderful thing to see coming in fresh leads on a daily basis by people who really want to learn more from you. If you wearInstead, the value of your business opportunities for the right people attracted to her and, of course, will raise the question: Do you have questions about your business. And if you generously share the knowledge with your prospects, it is easier to convert them or paying customers or new business partners.

Home business leads generation, can perform a simple task, but one must first learn to program. To learn more specifically on the generation of prospects in your business opportunitiesreading this FREE 43 page ebook titled "The Formula-3 step rule," which will explain how to publicize the lead, and monetize!

The bicycle is a good exercise to burn calories?

Of course it is! Cycling is one of the best exercises to burn calories. Whether it's riding a stationary bike at the gym, at home or outdoors, mountain biking burns more calories than almost any other exercise of a certain amount of time. Also, a bike ride is more fun than most other exercises.

Cycling is also much more user friendly for many forms of exercise. Is not the bear is a high-impact sports, which for the joints, such as running or aerobics manyExercises. There is also an exercise that can be enjoyed after a hip or knee.

The longer you stay, the more calories burned. The amount of calories burned during exercise bicycle or other depends on the time that are in operation with the intensity. This is a great advantage for cycling, because it is very easy to continue, riding a bicycle for an hour or more. The longer you stay, the more calories burned.

Most cyclists I know, can easily drive twoHours or more. Some of my friends are wonderful Randonneurs fanatics. Their races are anywhere from 60 to 750 miles at a time. These people drive day and night to reach their goals.

Speaking of long trips, I recently met a very beautiful young lady at the University of Texas at Austin, the team of cycling and just a drive from Austin, TX to Anchorage, Alaska and back in eighty days. They collected over 250,000 dollars for cancer research.

Then there is to Ride Across America (RAAM)Oceanside, CA to Atlantic City, NJ every year. This is a truly amazing race. The men's team is over 8 persons / h in 5 days and 16 minutes with an incredible average speed of 22.42 The race of men was only 8 days and 20 minutes produced an incredible average speed is also up 14.38 mph.

The drivers are incredible! I bet I can say about cycling calories.

Join a club Bicycles

Joining a cycling club, and you will have some very interestingPeople. Or take the CelebrateCycling.com Community meet other cyclists in your area. Do not worry about the seat bit 'bicycle, you'll soon get used to it. We all have.

Most drivers started with short strokes and slowly increased so that now, cycling is a part of their lives. Many of them join clubs or groups, where they enjoy long walks on weekends with friends on the quiet country roads. When I started, I thought 10 miles was a big problem, but now a trip to 30 milesWork twice a week is my norm. I also try to get a longer route for the weekend.

While they were in it are to burn calories in abundance. Let's look at a list of 200 calories per person burning books in various activities at a time to see how cycling compare:

Cycling for an hour at 12 mph = 725 calories
Running for one hour at 6 mph (10 miles min) = 908 calories
Basketball game for an hour = 725 calories
Rowing (Easy) for an 'hour = 862 calories
Skipping(Easy) for an 'hour = 908 calories
Aerobics (General) for an 'hour = 544 calories
Weightlifting (Easy) for an 'hour = 275 calories

You can see that cycling is up there with the rest, and do not take into account the list of turbulence and hills. You can slightly increase the calories burned cycling bicycling.The real reason is a great way to burn calories that biking outdoors more comfortable calling to return. There is always a new landscapeMagnificent views of the hills and a new conquest. There are friends to work with new lines and not to explore. Cycling is fun.
The bike is great, but you should also do something different. The bicycle is a good exercise for lower back and all your leg muscles, heart and circulation, but has not done much for your abdomen, chest, arms and upper back.

Spend a bit 'of time on the rest of the body will do wonders. If you already have conditioned your body to the discipline ofCycling, is ready to work upper body.

Groups of cyclists and clubs have members who are all shapes and sizes, but it is easy for those who recognize the wheel, along with some weights and core body temperature exercises like yoga and palates. They look great and have the shape of whole bodies, which we all wish we had.

Losing weight while in the strength and shape

We all know that exercise is important if you want to lose weight the right way. Burn caloriesThe bicycle is a great way to start, but we need a little 'more. We need to burn fat build muscle mass to reduce our body mass index (BMI). Wants to eat less and exercise more seems to be the right formula, but you can not.

Depending on what you can eat now, we need to eat more and exercise more. Our bodies are very complex machines. If we also exercise of moderate intensity for more than an hour, we need to eat, while we train.

Evencarbo, when we loaded for two days before our perception, our blood and liver to save only an hour and a half of power for a trained athlete. If we go over an hour to dry our tanks starts to run and we need a recharge. Passing an hour and a half, you begin to go into a hypoglycemic state, where riders bonk against the wall and cyclists. The two are not funny.

Bike ride for over an hour and a half, with no supplementary food is self-destructive. We not only from the energy sector and shaky, but we could beBurn some of these new muscle mass, which we have worked hard to build.

10,000 calories per month! To work! Calories burned can be easily by bike up to 10,000 per month or more. Would not it be great?

If we stop, we are all athletes, before we know it.

Dissolve Away those Pesky Bones with Corn Oil

I just read an interesting paper from Gabriel Fernandes's group at the University of Texas. It's titled "High fat diet-induced animal model of age-associated obesity and osteoporosis". I was expecting this to be the usual "we fed mice industrial lard for 60% of calories and they got sick" paper, but I was pleasantly surprised. From the introduction:
CO [corn oil] is known to promote bone loss, obesity, impaired glucose tolerance, insulin resistance and thus represents a useful model for studying the early stages in the development of obesity, hyperglycemia, Type 2 diabetes [23] and osteoporosis. We have used omega-6 fatty acids enriched diet as a fat source which is commonly observed in today's Western diets basically responsible for the pathogenesis of many diseases [24].
Just 10% of the diet as corn oil (roughly 20% of calories), with no added omega-3, on top of an otherwise poor laboratory diet, caused:
  • Obesity
  • Osteoporosis
  • The replacement of bone marrow with fat cells
  • Diabetes
  • Insulin resistance
  • Generalized inflammation
  • Elevated liver weight (possibly indicating fatty liver)
Hmm, some of these sound familiar... We can add them to the findings that omega-6 also promotes various types of cancer in rodents (1).

20% fat is less than the amount it typically takes to make a rodent this sick. This leads me to conclude that corn oil is particularly good at causing mouse versions of some of the most common facets of the "diseases of civilization". It's exceptionally high in omega-6 (linoleic acid) with virtually no omega-3.

Make sure to eat your heart-healthy corn oil! It's made in the USA, dirt cheap and it even lowers cholesterol!

Saturated Fat and Insulin Sensitivity

Insulin sensitivity is a measure of the tissue response to insulin. Typically, it refers to insulin's ability to cause tissues to absorb glucose from the blood. A loss of insulin sensitivity, also called insulin resistance, is a core part of the metabolic disorder that affects many people in industrial nations.

I don't know how many times I've seen the claim in journal articles and on the internet that saturated fat reduces insulin sensitivity. The idea is that saturated fat reduces the body's ability to handle glucose effectively, placing people on the road to diabetes, obesity and heart disease. Given the "selective citation disorder" that plagues the diet-health literature, perhaps this particular claim deserves a closer look.

The Evidence

I found a review article from 2008 that addressed this question (1). I like this review because it only includes high-quality trials that used reliable methods of determining insulin sensitivity*.

On to the meat of it. There were 5 studies in which non-diabetic people were fed diets rich in saturated fat, and compared with a group eating a diet rich in monounsaturated (like olive oil) or polyunsaturated (like corn oil) fat. They ranged in duration from one week to 3 months. Four of the five studies found that fat quality did not affect insulin sensitivity, including one of the 3-month studies.

The fifth study, which is the one that's nearly always cited in the diet-health literature, requires some discussion. This was the KANWU study (2). Over the course of three months, investigators fed 163 volunteers a diet rich in either saturated fat or monounsaturated fat.
The SAFA diet included butter and a table margarine containing a relatively high proportion of SAFAs. The MUFA diet included a spread and a margarine containing high proportions of oleic acid derived from high-oleic sunflower oil and negligible amounts of trans fatty acids and n-3 fatty acids and olive oil.
Yummy. After three months of these diets, there was no significant difference in insulin sensitivity between the saturated fat group and the monounsaturated fat group. Yes, you read that right. Even the study that's selectively cited as evidence that saturated fat causes insulin resistance found no significant difference between the diets. You might not get this by reading the misleading abstract. I'll be generous and acknowledge that the (small) difference was almost statistically significant (p = 0.053).

What the authors decided to focus on instead is the fact that insulin sensitivity declined slightly but significantly on the saturated fat diet compared with the pre-diet baseline. That's why this study is cited as evidence that saturated fat impairs insulin sensitivity. But anyone who has a basic science background will see where this reasoning is flawed (warning: nerd attack. skip the rest of the paragraph if you're not interested). You need a control group for comparison, to take into account normal fluctuations caused by such things as the season, eating mostly cafeteria food, and having a doctor hooking you up to machines. That control group was the group eating monounsaturated fat. The comparison between diet groups was the 'primary outcome', in statistics lingo. That's the comparison that matters, and it wasn't significant. To interpret the study otherwise is to ignore the basic conventions of statistics, which the authors were happy to do. There's a name for it: 'moving the goalpost'. The reviewers shouldn't have let this kind of shenanigans slide.

So we have five studies through 2008, none of which support the idea that saturated fat reduces insulin sensitivity in non-diabetics. Since the review paper was published, I know of one subsequent study that asked the same question (3). Susan J. van Dijk and colleagues fed volunteers with abdominal overweight (beer gut) a diet rich in either saturated fat or monounsaturated fat. I e-mailed the senior author and she said the saturated fat diet was "mostly butter". The specific fats used in the diets weren't mentioned anywhere in the paper, which is a major omission**. In any case, after 8 weeks, insulin sensitivity was virtually identical between the two groups. This study appeared well controlled and used the gold standard method for assessing insulin sensitivity, called the euglycemic-hyperinsulinemic clamp technique***.

The evidence from controlled trials is rather consistent that saturated fat has no appreciable effect on insulin sensitivity.

Why Are We so Focused on Saturated Fat?

Answer: because it's the nutrient everyone loves to hate. As an exercise in completeness, I'm going to mention three dietary factors that actually reduce insulin sensitivity, and get a lot less air time than saturated fat.

#1: Caffeine. That's right, controlled trials show that your favorite murky beverage reduces insulin sensitivity (4, 5). Is it actually relevant to real life? I doubt it. The doses used were large and the studies short-term.

#2: Magnesium deficiency. A low-magnesium diet reduced insulin sensitivity by 25% over the course of three weeks (6). I think this is probably relevant to long-term insulin sensitivity and overall health, although it would be good to have longer-term data. Magnesium deficiency is widespread in industrial nations, due to our over-reliance on refined foods such as sugar, white flour and oils.

#3: Sugar. Fructose reduces insulin sensitivity in humans, along with many other harmful effects (7).

As long as we continue to focus our energy on indicting saturated fat, it will continue distracting us from the real causes of disease.

* For the nerds: euglycemic-hyperinsulinemic clamp (the gold standard), insulin suppression test, or intravenous glucose tolerance test with Minimal Model. They didn't include studies that reported HOMA as their only measure, because it's not very accurate.

** There's this idea that pervades the diet-health literature that all saturated fats are roughly equivalent, all monounsaturated fats are equivalent, etc., therefore it doesn't matter what the source was. This is beyond absurd and reflects our cultural obsession with saturated fat. It really irks me that the reviewers didn't demand this information.

*** They did find that markers of inflammation in fat tissue were higher after the saturated fat diet.

Thank You

I'd like to extend my sincere thanks to everyone who has supported me through donations this year. The money has allowed me to buy materials that I wouldn't otherwise have been able to afford, and I feel it has enriched the blog for everyone. Here are some of the books I've bought using donations. Some were quite expensive:

Food and western disease: health and nutrition from an evolutionary perspective. Staffan Lindeberg (just released!!)

Nutrition and disease. Edward Mellanby

Migration and health in a small society: the case of Tokelau. Edited by Albert F. Wessen

The saccharine disease. T. L. Cleave

Culture, ecology and dental anthropology. John R. Lukacs

Vitamin K in health and disease. John W. Suttie

Craniofacial development. Geoffrey H. Sperber

Western diseases: their emergence and prevention. Hugh C. Trowell and Denis P. Burkitt

The ultimate omega-3 diet. Evelyn Tribole

Our changing fare. John Yudkin and colleagues

Donations have also paid for many, many photocopies at the medical library. I'd also like to thank everyone who participates in the community by leaving comments, or by linking to my posts. I appreciate your encouragement, and also the learning opportunities.